Esketamine nasal spray is used with or without an antidepressant taken by mouth, to treat depression in patients who have previously received at least 2 antidepressant treatments that did not work well (treatment-resistant depression).

Esketamine nasal spray is also used together with an antidepressant taken by mouth, to treat depressive symptoms in patients with major depressive disorder (MDD) with suicidal ideation or behavior.

This medicine is available only under a restricted distribution program called Spravato® REMS (Risk Evaluation and Mitigation Strategy) Program.
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What is SPRAVATO® (esketamine) CIII nasal spray?

SPRAVATO® is an NMDA receptor antagonist believed to work differently from traditional antidepressants by acting on glutamate
Glutamate=the most abundant neurotransmitter (chemical messenger) in the brain.

How can I get Spravato?
SPRAVATO® is a prescribed medication that comes in the form of a Nasal spray you self-administer under the supervision of a healthcare provider.

How is it administered?
SPRAVATO® can be taken with or without an oral antidepressant.

How does it work?
SPRAVATO® is believed to work differently from traditional antidepressants by acting on glutamate. The exact way SPRAVATO® works is unknown. While the exact role of glutamate in depression is unknown, it is a chemical messenger found in the brain that is thought to help balance well-being and depression.

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Schedule an evaluation at Foveo Healthcare, a professional medical corporation, today by calling (818) 254-9967 to determine if you’re a candidate for Spravato (Esketamine) therapy.

Spravato® (ESKETAMINE): Official patient website. SPRAVATO® (esketamine): A Prescription Nasal Spray. (n.d.). https://www.spravato.com/what-is-spravato/